The Association Between Epigenetic Clocks and Physical Functioning in Older Women: A 3-Year Follow-up.

ABSTRACT:

Background

Epigenetic clocks are composite markers developed to predict chronological age or mortality risk from DNA methylation (DNAm) data. The present study investigated the associations between 4 epigenetic clocks (Horvath's and Hannum's DNAmAge and DNAm GrimAge and PhenoAge) and physical functioning during a 3-year follow-up.

Method

We studied 63- to 76-year-old women (N = 413) from the Finnish Twin Study on Aging. DNAm was measured from blood samples at baseline. Age acceleration (AgeAccel), that is, discrepancy between chronological age and DNAm age, was determined as residuals from linear model. Physical functioning was assessed under standardized laboratory conditions at baseline and at follow-up. A cross-sectional analysis was performed with path models, and a long

SUBMITTER: Fohr T 

PROVIDER: S-EPMC9373966 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature