Zoledronate Extends Health Span and Survival via the Mevalonate Pathway in a FOXO-dependent Manner.

ABSTRACT: Over recent decades, increased longevity has not been paralleled by extended health span, resulting in more years spent with multiple diseases in older age. As such, interventions to improve health span are urgently required. Zoledronate (Zol) is a nitrogen-containing bisphosphonate, which inhibits the farnesyl pyrophosphate synthase enzyme, central to the mevalonate pathway. It is already used clinically to prevent fractures in osteoporotic patients, who have been reported to derive unexpected and unexplained survival benefits. Using Drosophila as a model we determined the effects of Zol on life span, parameters of health span (climbing ability and intestinal dysplasia), and the ability to confer resistance to oxidative stress using a combination of genetically manipulated Drosophila stra

SUBMITTER: Chen Z 

PROVIDER: S-EPMC9373971 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature