Relative Safety and Efficacy of Two Doses of Tandospirone Citrate for Generalized Anxiety Disorder: A Multicenter Randomized Controlled Trial.

ABSTRACT:

Purpose

To determine the relative safety and efficacy of different doses of tandospirone in treating generalized anxiety disorder (GAD).

Patients and methods

This parallel randomized controlled trial enrolled patients with GAD from eight centers in China. The patients were randomly assigned to 60 mg/day or 30 mg/day tandospirone groups. The primary endpoint was the overall response rate after receiving 6-week treatment. The secondary endpoints included significant response rate, clinical recovery rate, change in the Hamilton Anxiety Scale (HAMA) total score, HAMA subscale score, Hamilton Depression Scale-17 (HAMD-17), Clinical Global Impression-Severity Scale (CGI-S) score, and Impression-Improvement scale (CGI-I) score.

Results

No significant difference was found in

SUBMITTER: Li Q 

PROVIDER: S-EPMC9374096 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature