Development of an artificial synovial fluid useful for studying Staphylococcus epidermidis joint infections.

ABSTRACT: Staphylococcus epidermidis is a major causative agent of prosthetic joint infections (PJI). The ability to form biofilms supports this highly selective pathogenic potential. In vitro studies essentially relying on phenotypic assays and genetic approaches have provided a detailed picture of the molecular events contributing to biofilm assembly. A major limitation in these studies is the use of synthetic growth media, which significantly differs from the environmental conditions S. epidermidis encounters during host invasion. Building on evidence showing that growth in serum substantially affects S. epidermidis gene expression profiles and phenotypes, the major aim of this study was to develop and characterize a growth medium mimicking synovial fluid, thereby faci

SUBMITTER: Stamm J 

PROVIDER: S-EPMC9374174 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature