Egg excretion indicators for the measurement of soil-transmitted helminth response to treatment.

ABSTRACT:

Background

Periodic administration of anthelmintic drugs is a cost-effective intervention for morbidity control of soil-transmitted helminth (STH) infections. However, with programs expanding, drug pressure potentially selecting for drug-resistant parasites increases. While monitoring anthelmintic drug efficacy is crucial to inform country control program strategies, different factors must be taken into consideration that influence drug efficacy and make it difficult to standardize treatment outcome measures. We aimed to identify suitable approaches to assess and compare the efficacy of different anthelmintic treatments.

Methodology

We built an individual participant-level database from 11 randomized controlled trials and two observational studies in which subjects received

SUBMITTER: Olliaro PL 

PROVIDER: S-EPMC9374261 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature