Assessing the importance of sex in a hippocampus-dependent behavioral test battery in C57BL/6NTac mice.

ABSTRACT: Inclusion of male and female subjects in behavioral neuroscience research requires a concerted effort to characterize sex differences in standardized behavioral assays. Sex differences in hippocampus-dependent assays have been widely reported but are still poorly characterized. In the present study, we conducted a parametric analysis of spontaneous alternation, object recognition, and fear conditioning in a commonly used control strain, C57BL/6NTac. Our findings show largely similar performance between males and females across the majority of behavioral end points. However, we identified an important difference in nonassociative fear sensitization, whereby females showed an enhanced fear response to the 75-dB tone that is used as the conditional stimulus. In addition, we observed an impair

SUBMITTER: Stevanovic KD 

PROVIDER: S-EPMC9374270 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature