Persistent up-regulation of polyribosomes at synapses during long-term memory, reconsolidation, and extinction of associative memory.

ABSTRACT: Local protein synthesis at synapses can provide a rapid supply of proteins to support synaptic changes during consolidation of new memories, but its role in the maintenance or updating of established memories is unknown. Consolidation requires new protein synthesis in the period immediately following learning, whereas established memories are resistant to protein synthesis inhibitors. We have previously reported that polyribosomes are up-regulated in the lateral amygdala (LA) during consolidation of aversive-cued Pavlovian conditioning. In this study, we used serial section electron microscopy reconstructions to determine whether the distribution of dendritic polyribosomes returns to baseline during the long-term memory phase. Relative to control groups, long-term memory was associated wit

SUBMITTER: Ostroff LE 

PROVIDER: S-EPMC9374273 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature