Noninvasive interrogation of CD8+ T cell effector function for monitoring early tumor responses to immunotherapy.

ABSTRACT: Accurately identifying patients who respond to immunotherapy remains clinically challenging. A noninvasive method that can longitudinally capture information about immune cell function and assist in the early assessment of tumor responses is highly desirable for precision immunotherapy. Here, we show that PET imaging using a granzyme B-targeted radiotracer named 68Ga-grazytracer, could noninvasively and effectively predict tumor responses to immune checkpoint inhibitors and adoptive T cell transfer therapy in multiple tumor models. 68Ga-grazytracer was designed and selected from several radiotracers based on non-aldehyde peptidomimetics, and exhibited excellent in vivo metabolic stability and favorable targeting efficiency to granzyme B secreted by effector CD8+ T cells during immune respo

SUBMITTER: Zhou H 

PROVIDER: S-EPMC9374377 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature