Information flows from hippocampus to auditory cortex during replay of verbal working memory items.

ABSTRACT: The maintenance of items in working memory (WM) relies on a widespread network of cortical areas and hippocampus where synchronization between electrophysiological recordings reflects functional coupling. We investigated the direction of information flow between auditory cortex and hippocampus while participants heard and then mentally replayed strings of letters in WM by activating their phonological loop. We recorded local field potentials from the hippocampus, reconstructed beamforming sources of scalp EEG, and - additionally in four participants - recorded from subdural cortical electrodes. When analyzing Granger causality, the information flow was from auditory cortex to hippocampus with a peak in the [4 8] Hz range while participants heard the letters. This flow was subsequent

SUBMITTER: Dimakopoulos V 

PROVIDER: S-EPMC9374435 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature