Distinct roles for two Caenorhabditis elegans acid-sensing ion channels in an ultradian clock.
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ABSTRACT:
SUBMITTER: Kaulich E
PROVIDER: S-EPMC9374441 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
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Distinct roles for two <i>Caenorhabditis elegans</i> acid-sensing ion channels in an ultradian clock.
Kaulich Eva E Carroll Trae T Ackley Brian D BD Tang Yi-Quan YQ Hardege Iris I Nehrke Keith K Schafer William R WR Walker Denise S DS
eLife 20220606
Biological clocks are fundamental to an organism's health, controlling periodicity of behaviour and metabolism. Here, we identify two acid-sensing ion channels, with very different proton sensing properties, and describe their role in an ultradian clock, the defecation motor program (DMP) of the nematode <i>Caenorhabditis elegans</i>. An ACD-5-containing channel, on the apical membrane of the intestinal epithelium, is essential for maintenance of luminal acidity, and thus the rhythmic oscillatio ...[more]
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