Bioinformatic analysis of PD-1 checkpoint blockade response in influenza infection.

ABSTRACT:

Background

The programmed cell death 1 (PD-1)/PD-1 ligand 1 (PD-L1) signaling pathway is significantly upregulated in influenza virus infection, which impairs the antiviral response. Blocking this signaling pathway may reduce the damage, lower the virus titer in lung tissue, and alleviate the symptoms of infection to promote recovery. In addition to the enhanced viral immune response, using of immune checkpoint inhibitors in influenza virus infection is controversial, the aim of this study was to identify the key factors and regulatory mechanisms in the PD-1 checkpoint blockade response microenvironment in influenza infection.

Methods

A BALB/c mouse model of influenza A/PR8(H1N1) infection was established then constructed, and whole-transcriptome sequencing including mRNAs,

SUBMITTER: Ou H 

PROVIDER: S-EPMC9374577 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature