Metabolomic changes in cats with renal disease and calcium oxalate uroliths.

ABSTRACT:

Introduction

There is a significant incidence of cats with renal disease (RD) and calcium oxalate (CaOx) kidney uroliths in domesticated cats. Foods which aid in the management of these diseases may be enhanced through understanding the underlying metabolomic changes.

Objective

Assess the metabolomic profile with a view to identifying metabolomic targets which could aid in the management of renal disease and CaOx uroliths.

Method

This is a retrospective investigation of 42 cats: 19 healthy kidney controls, 11 with RD, and 12 that formed CaOx nephroliths. Cats were evaluated as adults (2 through 7 years) and at the end of life for plasma metabolomics, body composition, and markers of renal dysfunction. Kidney sections were assessed by Pizzolato stain at the end of life

SUBMITTER: Jewell DE 

PROVIDER: S-EPMC9374649 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature