Connectomic assessment of injury burden and longitudinal structural network alterations in moderate-to-severe traumatic brain injury.

ABSTRACT: Traumatic brain injury (TBI) is a major public health problem. Caused by external mechanical forces, a major characteristic of TBI is the shearing of axons across the white matter, which causes structural connectivity disruptions between brain regions. This diffuse injury leads to cognitive deficits, frequently requiring rehabilitation. Heterogeneity is another characteristic of TBI as severity and cognitive sequelae of the disease have a wide variation across patients, posing a big challenge for treatment. Thus, measures assessing network-wide structural connectivity disruptions in TBI are necessary to quantify injury burden of individuals, which would help in achieving personalized treatment, patient monitoring, and rehabilitation planning. Despite TBI being a disconnectivity syndrome, c

SUBMITTER: Osmanlıoglu Y 

PROVIDER: S-EPMC9374876 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature