Brain serotonin transporter is associated with cognitive-affective biases in healthy individuals.

ABSTRACT: Cognitive affective biases describe the tendency to process negative information or positive information over the other. These biases can be modulated by changing extracellular serotonin (5-HT) levels in the brain, for example, by pharmacologically blocking and downregulating the 5-HT transporter (5-HTT), which remediates negative affective bias. This suggests that higher levels of 5-HTT are linked to a priority of negative information over positive, but this link remains to be tested in vivo in healthy individuals. We, therefore, evaluated the association between 5-HTT levels, as measured with [¹¹ C]DASB positron emission tomography (PET), and affective biases, hypothesising that higher 5-HTT levels are associated with a more negative bias. We included 98 healthy individuals wi

SUBMITTER: Armand S 

PROVIDER: S-EPMC9374883 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature