Spindle-slow oscillation coupling correlates with memory performance and connectivity changes in a hippocampal network after sleep.

ABSTRACT: After experiences are encoded, post-encoding reactivations during sleep have been proposed to mediate long-term memory consolidation. Spindle-slow oscillation coupling during NREM sleep is a candidate mechanism through which a hippocampal-cortical dialogue may strengthen a newly formed memory engram. Here, we investigated the role of fast spindle- and slow spindle-slow oscillation coupling in the consolidation of spatial memory in humans with a virtual watermaze task involving allocentric and egocentric learning strategies. Furthermore, we analyzed how resting-state functional connectivity evolved across learning, consolidation, and retrieval of this task using a data-driven approach. Our results show task-related connectivity changes in the executive control network, the default mode netw

SUBMITTER: Bastian L 

PROVIDER: S-EPMC9374888 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature