Left amygdala structure mediates longitudinal associations between exposure to threat and long-term psychiatric symptomatology in youth.

ABSTRACT: Traumatic experiences during childhood can have profound effects on stress sensitive brain structures (e.g., amygdala and hippocampus) and the emergence of psychiatric symptoms. Recent theoretical and empirical work has delineated dimensions of trauma (i.e., threat and deprivation) as having distinct neural and behavioral effects, although there are few longitudinal examinations. A sample of 243 children and adolescents were followed for three time points, with each assessment approximately 1 year apart (ages 9-15 years at Time 1; 120 males). Participants or their caregiver reported on youths' threat exposure, perceived stress (Time 1), underwent a T1-weighted structural high-resolution MRI scan (Time 2), and documented their subsequent psychiatric symptoms later in development (Time 3). T

SUBMITTER: Picci G 

PROVIDER: S-EPMC9374891 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature