Physiological instability is linked to mortality in primary central nervous system lymphoma: A case-control fMRI study.

ABSTRACT: Primary central nervous system lymphoma (PCNSL) is an aggressive brain disease where lymphocytes invade along perivascular spaces of arteries and veins. The invasion markedly changes (peri)vascular structures but its effect on physiological brain pulsations has not been previously studied. Using physiological magnetic resonance encephalography (MREG_BOLD ) scanning, this study aims to quantify the extent to which (peri)vascular PCNSL involvement alters the stability of physiological brain pulsations mediated by cerebral vasculature. Clinical implications and relevance were explored. In this study, 21 PCNSL patients (median 67y; 38% females) and 30 healthy age-matched controls (median 63y; 73% females) were scanned for MREG_BOLD signal during 2018-2021. Motion effects we

SUBMITTER: Poltojainen V 

PROVIDER: S-EPMC9374894 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature