COVID-19 Adaptive Humoral Immunity Models: Weakly Neutralizing Versus Antibody-Disease Enhancement Scenarios.

ABSTRACT: The interplay between the virus, infected cells and immune responses to SARS-CoV-2 is still under debate. By extending the basic model of viral dynamics, we propose here a formal approach to describe neutralisation versus weak (or non-)neutralisation scenarios and compare them with the possible effects of antibody-dependent enhancement (ADE). The theoretical model is consistent with the data available in the literature; we show that both weakly neutralising antibodies and ADE can result in final viral clearance or disease progression, but that the immunodynamics are different in each case. As a significant proportion of the world's population is already naturally immune or vaccinated, we also discuss the implications for secondary infections after vaccination or in the presence of immune s

SUBMITTER: Danchin A 

PROVIDER: S-EPMC9375081 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature