Mass defect filtering for suspect screening of halogenated environmental chemicals: A case study of chlorinated organophosphate flame retardants.

ABSTRACT:

Rationale

Organophosphate flame retardants (OPFRs) are a class of flame retardants widely found in environmental and biological matrices that have been extensively studied due to their adverse health effects in humans. OPFRs are loosely bound chemicals that can detach from treated products and be released into indoor and outdoor environments, where they have the potential to further undergo transformation and degradation processes, in particular the chlorinated OPFRs (Cl-PFRs). Their detection remains a moving target for analysts, and traditional targeted mass spectrometry methods are suitable only for those compounds with authentic standards.

Methods

Mass defect filter (MDF) is a strategy to filter molecular features using thresholds applied to the mass defect value of a ta

SUBMITTER: Dolios G 

PROVIDER: S-EPMC9375139 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature