Antidepressant use and risk of self-harm among people aged 40 years or older: A population-based cohort and self-controlled case series study.

ABSTRACT:

Background

Studies on the association between antidepressants and self-harm in adults were mostly conducted over a decade ago and have inconsistent findings. We aimed to compare self-harm risks by antidepressant classes among people aged 40 years or older with depression.

Methods

Individuals aged ≥40 years with depression who initiated antidepressant treatment between 2001 and 2015 were retrieved from the Hong Kong Clinical Data Analysis & Reporting system, and were followed up until December 31, 2016. We conducted self-controlled case series (SCCS) analyses to estimate the incidence rate ratio (IRR) of self-harm comparing the pre-exposure (90 days before the first antidepressant use), index exposure (the first antidepressant use), and subsequent exposure (subsequent antidep

SUBMITTER: Chai Y 

PROVIDER: S-EPMC9375149 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature