Coexistence of Eph receptor B1 and ephrin B2 in port-wine stain endothelial progenitor cells contributes to clinicopathological vasculature dilatation.

ABSTRACT:

Background

Port-wine stain (PWS) is a vascular malformation characterized by progressive dilatation of postcapillary venules, but the molecular pathogenesis remains obscure.

Objectives

To illustrate that PWS endothelial cells (ECs) present a unique molecular phenotype that leads to pathoanatomical PWS vasculatures.

Methods

Immunohistochemistry and transmission electron microscopy were used to characterize the ultrastructure and molecular phenotypes of PWS blood vessels. Primary culture of human dermal microvascular endothelial cells and in vitro tube formation assay were used for confirmative functional studies.

Results

Multiple clinicopathological features of PWS blood vessels during the development and progression of the disease were shown. There were no norm

SUBMITTER: Tan W 

PROVIDER: S-EPMC9375175 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature