WISP1 induces ovarian cancer via the IGF1/αvβ3/Wnt axis.

ABSTRACT:

Background

This study intended to clarify the mechanisms by which WISP1-mediated IGF1/αvβ3/Wnt axis might affect the progression of ovarian cancer.

Methods

Bioinformatics analysis was implemented for pinpointing expression of IGF1 and WISP1 which was verified through expression determination in clinical tissue samples and cells. Next, gain- or loss-of-function experimentations were implemented for testing CAOV4 and SKOV3 cell biological processes. The interaction between WISP1 and IGF1 was verified by co-immunoprecipitation and the molecular mechanism was analyzed. Finally, ovarian cancer nude mouse models were prepared to unveil the in vivo effects of WISP1/IGF1.

Results

IGF1 and WISP1 expression was elevated in ovarian cancer tissues and cells, which shared correlat

SUBMITTER: Li Y 

PROVIDER: S-EPMC9375285 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature