TOMM40 genetic variants associated with healthy aging and longevity: a systematic review.

ABSTRACT:

Introduction

Healthy aging relies on mitochondrial functioning because this organelle provides energy and diminishes oxidative stress. Single nucleotide polymorphisms (SNPs) in TOMM40, a critical gene that produces the outer membrane protein TOM40 of mitochondria, have been associated with mitochondrial dysfunction and neurodegenerative processes. Yet it is not clear whether or how the mitochondria may impact human longevity. We conducted this review to ascertain which SNPs have been associated with markers of healthy aging.

Methods

Using the PRISMA methodology, we conducted a systematic review on PubMed and Embase databases to identify associations between TOMM40 SNPs and measures of longevity and healthy aging.

Results

Twenty-four articles were selected. The TOMM40

SUBMITTER: Chen S 

PROVIDER: S-EPMC9375314 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature