Genetic variants of interleukin 1B and 6 are associated with clinical outcome of surgically treated lumbar degenerative disc disease.

ABSTRACT:

Background

Successfully surgically treating degenerative disc diseases can be challenging to the spine surgeons, the long-term outcome relies on both the physical and mental status of the patient before and after treatment. Numerous studies underlined the role of inflammatory cytokines - like interleukin 1B and 6 - in the development of chronic diseases such as failed back surgery syndrome (FBSS) and major depressive disorder (MDD) which alter the outcome after spinal surgery. Our aim was to evaluate the associations of IL6 and IL1B gene polymorphisms with the long-term outcome of degenerative lumbar spine surgeries.

Methods

An international genetical database (GENODISC) was combined with our institute's clinical database to create a large pool with long term follow up data.

SUBMITTER: Biczo A 

PROVIDER: S-EPMC9375337 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature