Polygenic Risk, Midlife Life's Simple 7, and Lifetime Risk of Stroke.

ABSTRACT: Background Recent genetic discoveries in stroke have unleashed the potential of using genetic information for risk prediction and health interventions aimed at disease prevention. We sought to estimate the lifetime risk of stroke (LTRS) by levels of genetic risk and to investigate whether optimal cardiovascular health can offset the negative impact of high genetic risk on lifetime risk of stroke. Methods and Results Study participants were 11 568 middle-aged adults (56% women, 23% Black adults), who were free of stroke at baseline and were followed up for a median of 28 years. The remaining LTRS was estimated according to levels of genetic risk based on a validated stroke polygenic risk score, and to levels of cardiovascular health based on the American Heart Association Life's Simple 7 re

SUBMITTER: Thomas EA 

PROVIDER: S-EPMC9375491 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature