Maternal gut microbiome-induced IgG regulates neonatal gut microbiome and immunity.

ABSTRACT: The gut microbiome elicits antigen-specific immunoglobulin G (IgG) at steady state that cross-reacts to pathogens to confer protection against systemic infection. The role of gut microbiome-specific IgG antibodies in the development of the gut microbiome and immunity against enteric pathogens in early life, however, remains largely undefined. In this study, we show that gut microbiome-induced maternal IgG is transferred to the neonatal intestine through maternal milk via the neonatal Fc receptor and directly inhibits Citrobacter rodentium colonization and attachment to the mucosa. Enhanced neonatal immunity against oral C. rodentium infection was observed after maternal immunization with a gut microbiome-derived IgG antigen, outer membrane protein A, or induction of IgG-induc

SUBMITTER: Sanidad KZ 

PROVIDER: S-EPMC9375732 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature