Two major genes associated with autoimmune arthritis, Ncf1 and Fcgr2b, additively protect mice by strengthening T cell tolerance.

ABSTRACT: A breach of T cell tolerance is considered as a major step in the pathogenesis of rheumatoid arthritis. In collagen-induced arthritis (CIA) model, immunization with type II collagen (COL2) leads to arthritis in mice through T cells responding to the immunodominant COL2_259-273 peptide. T cells could escape from thymus negative selection because endogenous COL2_259-273 peptide only weakly binds to the major histocompatibility complex class II (MHCII) molecule A^q. To investigate the regulation of T cell tolerance, we used a new mouse strain BQ.Col2^266E with homozygous D266E mutations in the Col2 gene leading to a replacement of the endogenous aspartic acid (D) to glutamic acid (E) at position 266 of the COL2_259-273 peptide, resulting in st

SUBMITTER: Li Q 

PROVIDER: S-EPMC9375767 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature