D-dopachrome tautomerase drives astroglial inflammation via NF-κB signaling following spinal cord injury.

ABSTRACT:

Background

Reactive astrocytes are increasingly recognized as crucial regulators of innate immunity in degenerative or damaged central nervous system (CNS). Many proinflammatory mediators have been shown to drive inflammatory cascades of astrocytes through activation of NF-κB, thereby affecting the functional outcome of the insulted CNS. D-dopachrome tautomerase (D-DT), a newly described cytokine and a close homolog of proinflammatory macrophage migration inhibitory factor (MIF), has been revealed to share receptor and overlapping functional spectrum with MIF, but little is known about its roles in the neuropathological progression of the CNS and relevant regulatory mechanisms.

Results

D-DT protein levels were significantly elevated within neurons and astrocytes following SC

SUBMITTER: Li H 

PROVIDER: S-EPMC9375920 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature