Functions and mechanisms of protein disulfide isomerase family in cancer emergence.

ABSTRACT: The endoplasmic reticulum (ER) is a multi-layered organelle that is essential for the synthesis, folding, and structural maturation of almost one-third of the cellular proteome. It houses several resident proteins for these functions including the 21 members of the protein disulfide isomerase (PDI) family. The signature of proteins belonging to this family is the presence of the thioredoxin domain which mediates the formation, and rearrangement of disulfide bonds of substrate proteins in the ER. This process is crucial not only for the proper folding of ER substrates but also for maintaining a balanced ER proteostasis. The inclusion of new PDI members with a wide variety of structural determinants, size and enzymatic activity has brought additional epitomes of how PDI functions. Notably, s

SUBMITTER: Rahman NSA 

PROVIDER: S-EPMC9375924 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature