CD147 mediates epidermal malignant transformation through the RSK2/AP-1 pathway.

ABSTRACT:

Background

Malignant transformation of the epidermis is an essential process in the pathogenesis of cutaneous squamous-cell carcinoma (cSCC). Although evidence has demonstrated that CD147 plays key roles in various tumors, the role of CD147 in epidermal malignant transformation in vivo remains unclear.

Methods

Epidermal CD147-overexpression or knockout (Epi^CD147-OE or Epi^CD147-KO) transgenic mouse models were generated for in vivo study. RNA-sequencing and q-PCR were performed to identify the differentially expressed genes. Immunohistochemistry and flow cytometry were performed to investigate the role of CD147 in regulating myeloid-derived suppressor cells (MDSCs). Immunoprecipitation, EMSA and ChIP assays were performed to investigate the mechanism of

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9375950 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature