Novel Driver Strength Index highlights important cancer genes in TCGA PanCanAtlas patients.

ABSTRACT:

Background

Cancer driver genes are usually ranked by mutation frequency, which does not necessarily reflect their driver strength. We hypothesize that driver strength is higher for genes preferentially mutated in patients with few driver mutations overall, because these few mutations should be strong enough to initiate cancer.

Methods

We propose formulas for the Driver Strength Index (DSI) and the Normalized Driver Strength Index (NDSI), the latter independent of gene mutation frequency. We validate them using TCGA PanCanAtlas datasets, established driver prediction algorithms and custom computational pipelines integrating SNA, CNA and aneuploidy driver contributions at the patient-level resolution.

Results

DSI and especially NDSI provide substantially different gene

SUBMITTER: Belikov AV 

PROVIDER: S-EPMC9375969 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature