The dual action of glioma-derived exosomes on neuronal activity: synchronization and disruption of synchrony.

ABSTRACT: Seizures represent a frequent symptom in gliomas and significantly impact patient morbidity and quality of life. Although the pathogenesis of tumor-related seizures is not fully understood, accumulating evidence indicates a key role of the peritumoral microenvironment. Brain cancer cells interact with neurons by forming synapses with them and by releasing exosomes, cytokines, and other small molecules. Strong interactions among neurons often lead to the synchronization of their activity. In this paper, we used an in vitro model to investigate the role of exosomes released by glioma cell lines and by patient-derived glioma stem cells (GSCs). The addition of exosomes released by U87 glioma cells to neuronal cultures at day in vitro (DIV) 4, when neurons are not yet synchronous, induces synch

SUBMITTER: Spelat R 

PROVIDER: S-EPMC9376103 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature