A retrospective study of the efficacy and safety of naldemedine for opioid-induced constipation in thoracic cancer patients.

ABSTRACT:

Background

We conducted a multicenter, retrospective study on the efficacy and safety of naldemedine in thoracic cancer patients using opioids in clinical practice.

Methods

We retrospectively evaluated thoracic cancer patients treated with naldemedine at 10 institutions in Japan. Clinical data of patients administered naldemedine between June 2017 and August 2019 were extracted from electronic medical records. Inclusion criteria were as follows: (i) patients hospitalized for at least seven days before and after naldemedine administration, and (ii) those whose frequency of defecation was entered in the medical records.

Results

Forty patients were analyzed, and defecation frequency was observed for at least seven days before and after naldemedine administration. The res

SUBMITTER: Imai H 

PROVIDER: S-EPMC9376157 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature