Ontology highlight
ABSTRACT:
SUBMITTER: Ghorbaninezhad F
PROVIDER: S-EPMC9376327 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Ghorbaninezhad Farid F Masoumi Javad J Bakhshivand Mohammad M Baghbanzadeh Amir A Mokhtarzadeh Ahad A Kazemi Tohid T Aghebati-Maleki Leili L Shotorbani Siamak Sandoghchian SS Jafarlou Mahdi M Brunetti Oronzo O Santarpia Mariacarmela M Baradaran Behzad B Silvestris Nicola N
Frontiers in immunology 20220801
Dendritic cell (DC)-based immunotherapy has increased interest among anti-cancer immunotherapies. Nevertheless, the immunosuppressive mechanisms in the tumor milieu, e.g., inhibitory immune checkpoint molecules, have been implicated in diminishing the efficacy of DC-mediated anti-tumoral immune responses. Therefore, the main challenge is to overcome inhibitory immune checkpoint molecules and provoke efficient T-cell responses to antigens specifically expressed by cancerous cells. Among the inhib ...[more]