Herpesvirus entry mediator on T cells as a protective factor for myasthenia gravis: A Mendelian randomization study.

ABSTRACT:

Background and objectives

Myasthenia gravis (MG) is a T cell-driven, autoantibody-mediated disorder affecting transmission in neuromuscular junctions. The associations between the peripheral T cells and MG have been extensively studied. However, they are mainly of observational nature, thus limiting our understanding of the effect of inflammatory biomarkers on MG risk. With large data sets now available, we used Mendelian randomization (MR) analysis to investigate whether the biomarkers on T cells are causally associated with MG and further validate the relationships.

Methods

We performed a two-sample MR analysis using genetic data from one genome-wide association study (GWAS) for 210 extensive T-cell traits in 3,757 general population individuals and the largest GWAS for MG

SUBMITTER: Zhong H 

PROVIDER: S-EPMC9376372 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature