Psychiatric risk gene transcription factor 4 preferentially regulates cortical interneuron neurogenesis during early brain development.

ABSTRACT: Genetic variants within or near the transcription factor 4 gene ( TCF4) are robustly implicated in psychiatric disorders including schizophrenia. However, the biological pleiotropy poses considerable obstacles to dissect the potential relationship between TCF4 and those highly heterogeneous diseases. Through integrative transcriptomic analysis, we demonstrated that TCF4 is preferentially expressed in cortical interneurons during early brain development. Therefore, disruptions of interneuron development might be the underlying contribution of TCF4 perturbation to a range of neurodevelopmental disorders. Here, we performed chromatin immunoprecipitation sequencing (ChIP-seq) of TCF4 on human medial ganglionic eminence-like organoids (hMGEOs) to identify genome-wide TCF4 b

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9376727 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature