Risk of acute liver injury following the mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccines.

ABSTRACT:

Background & aims

Case reports of severe acute liver injury (ALI) following COVID-19 vaccination have recently been published. We evaluated the risks of ALI following COVID-19 vaccination (BNT162b2 or CoronaVac).

Methods

We conducted a modified self-controlled case series analysis using the vaccination records in Hong Kong with data linkage to electronic medical records from a territory-wide healthcare database. Incidence rate ratios (IRRs) for ALI outcome in the 56-day period following first and second doses of COVID-19 vaccines in comparison to the non-exposure period were estimated and compared to the ALI risk in patients with SARS-CoV-2 infection.

Results

Among 2,343,288 COVID-19 vaccine recipients who were at risk, 4,677 patients developed ALI for the first time

SUBMITTER: Wong CKH 

PROVIDER: S-EPMC9376738 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature