Quantifying the Human Subchondral Trabecular Bone Microstructure in Osteoarthritis with Clinical CT.

ABSTRACT: Osteoarthritis (OA) is characterized by critical alterations of the subchondral bone microstructure, besides the well-known cartilaginous changes. Clinical computed tomography (CT) detection of quantitative 3D microstructural subchondral bone parameters is applied to monitor changes of subchondral bone structure in different stages of human OA and is compared with micro-CT, the gold standard. Determination by clinical CT (287 µm resolution) of key microstructural parameters in tibial plateaus with mild-to-moderate and severe OA reveals strong correlations to micro-CT (35 µm), high inter- and intraobserver reliability, and small relative differences. In vivo, normal, mild-to-moderate, and severe OA are compared with clinical CT (331 µm). All approaches detect characteristic expanded trabecu

SUBMITTER: Olah T 

PROVIDER: S-EPMC9376842 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature