Ultrasensitive Detection of Biomarkers in a Color-Switchable Microcavity-Reactor Laser.

ABSTRACT: Early detection and diagnosis are vitally important in reducing the mortality rate of fatal diseases but require highly sensitive detection of biomarkers. Presently, detection methods with the highest sensitivity require in vitro processing, while in vivo compatible fluorescence detections require a much higher concentration of biomarkers or limit of detection (LOD). In this paper, a fundamentally new strategy for ultrasensitive detection based on color-switchable lasing with a cavity-enhanced reduction of LOD is demonstrated, down to 1.4 × 10^-16  mg ml^-1 for a quantitative detection, lower than both the fluorescence method and plasmonic enhanced method. For a qualitative or a yes/no type of detection, the LOD is as low as 10^-17  mg ml^-1 . The ap

SUBMITTER: Li R 

PROVIDER: S-EPMC9376852 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature