MOTUpan: a robust Bayesian approach to leverage metagenome-assembled genomes for core-genome estimation.

ABSTRACT: Recent advances in sequencing and bioinformatics have expanded the tree of life by providing genomes for uncultured environmentally relevant clades, either through metagenome-assembled genomes or through single-cell genomes. While this expanded diversity can provide novel insights into microbial population structure, most tools available for core-genome estimation are sensitive to genome completeness. Consequently, a major portion of the huge phylogenetic diversity uncovered by environmental genomic approaches remains excluded from such analyses. We present mOTUpan, a novel iterative Bayesian method for computing the core genome for sets of genomes of highly diverse completeness range. The likelihood for each gene cluster to belong to core or accessory genome is estimated by computing the

SUBMITTER: Buck M 

PROVIDER: S-EPMC9376867 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature