Bioengineered textiles with peptide binders that capture SARS-CoV-2 viral particles.

ABSTRACT: The use of personal protective equipment (PPE), face masks and ventilation are key strategies to control the transmission of respiratory viruses. However, most PPE provides physical protection that only partially prevents the transmission of viral particles. Here, we develop textiles with integrated peptide binders that capture viral particles. We fuse peptides capable of binding the receptor domain of the spike protein on the SARS-CoV-2 capsid to the cellulose-binding domain from the Trichoderma reesei cellobiohydrolase II protein. The hybrid peptides can be attached to the cellulose fibres in cotton and capture SARS-CoV-2 viral particles with high affinity. The resulting bioengineered cotton captures 114,000 infective virus particles per cm² and reduces onwards SARS-CoV

SUBMITTER: Navone L 

PROVIDER: S-EPMC9376897 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature