Maternal and child genetic liability for smoking and caffeine consumption and child mental health: an intergenerational genetic risk score analysis in the ALSPAC cohort.

ABSTRACT:

Background and aims

Previous studies suggest an association between maternal tobacco and caffeine consumption during and outside of pregnancy and offspring mental health. We aimed to separate effects of the maternal environment (intrauterine or postnatal) from pleiotropic genetic effects.

Design

Secondary analysis of a longitudinal study. We (i) validated smoking and caffeine genetic risk scores (GRS) derived from published genome-wide association study (GWAS) for use during pregnancy, (ii) compared estimated effects of maternal and offspring GRS on childhood mental health outcomes and (iii) tested associations between maternal and offspring GRS on their respective outcomes.

Setting

We used data from a longitudinal birth cohort study from England, the Avon Longitudina

SUBMITTER: Schellhas L 

PROVIDER: S-EPMC9376939 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature