Plasma metabolomic profiles of dementia: a prospective study of 110,655 participants in the UK Biobank.

ABSTRACT:

Background

Plasma metabolomic profile is disturbed in dementia patients, but previous studies have discordant conclusions.

Methods

Circulating metabolomic data of 110,655 people in the UK Biobank study were measured with nuclear magnetic resonance technique, and incident dementia records were obtained from national health registers. The associations between plasma metabolites and dementia were estimated using Cox proportional hazard models. The 10-fold cross-validation elastic net regression models selected metabolites that predicted incident dementia, and a 10-year prediction model for dementia was constructed by multivariable logistic regression. The predictive values of the conventional risk model, the metabolites model, and the combined model were discriminated by compar

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9377110 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature