CCM signaling complex (CSC) couples both classic and non-classic Progesterone receptor signaling.

ABSTRACT:

Background

Breast cancer, the most diagnosed cancer, remains the second leading cause of cancer death in the United States, and excessive Progesterone (PRG) or Mifepristone (MIF) exposure may be at an increased risk for developing breast cancer. PRG exerts its cellular responses through signaling cascades involving classic, non-classic, or combined responses by binding to either classic nuclear PRG receptors (nPRs) or non-classic membrane PRG receptors (mPRs). Currently, the intricate balance and switch mechanisms between these two signaling cascades remain elusive. Three genes, CCM1-3, form the CCM signaling complex (CSC) which mediates multiple signaling cascades.

Methods

Utilizing molecular, cellular, Omics, and systems biology approaches, we analyzed the relationship amo

SUBMITTER: Abou-Fadel J 

PROVIDER: S-EPMC9377144 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature