A preclinical study of diffusion-weighted MRI contrast as an early indicator of thermal ablation.

ABSTRACT:

Purpose

Intraoperative T₂ -weighted (T2-w) imaging unreliably captures image contrast specific to thermal ablation after transcranial MR-guided focused ultrasound surgery, impeding dynamic imaging feedback. Using a porcine thalamotomy model, we test the unproven hypothesis that intraoperative DWI can improve dynamic feedback by detecting lesioning within 30 minutes of transcranial MR-guided focused ultrasound surgery.

Methods

Twenty-five thermal lesions were formed in six porcine models using a clinical transcranial MR-guided focused ultrasound surgery system. A novel diffusion-weighted pulse sequence monitored the formation of T2-w and diffusion-weighted lesion contrast after ablation. Using postoperative T2-w contrast to indicate lesioning, apparent intraoperati

SUBMITTER: Allen SP 

PROVIDER: S-EPMC9377372 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature