Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever.

ABSTRACT: We have previously demonstrated that Mucosal-Associated Invariant T (MAIT) cells secrete multiple cytokines after exposure to Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever in humans. However, whether cytokine secreting MAIT cells can enhance or attenuate the clinical severity of bacterial infections remain debatable. This study characterizes human MAIT cell functions in subjects participating in a wild-type S. Typhi human challenge model. Here, we found that MAIT cells exhibit distinct functional signatures associated with protection against typhoid fever. We also observed that the cytokine patterns of MAIT cell responses, rather than the average number of cytokines expressed, are more predictive of typhoid fever outcomes. These results might enable us

SUBMITTER: Salerno-Goncalves R 

PROVIDER: S-EPMC9377420 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature