Increased functional connectivity of white-matter in myotonic dystrophy type 1.

ABSTRACT:

Background

Myotonic dystrophy type 1 (DM1) is the most common and dominant inherited neuromuscular dystrophy disease in adults, involving multiple organs, including the brain. Although structural measurements showed that DM1 is predominantly associated with white-matter damage, they failed to reveal the dysfunction of the white-matter. Recent studies have demonstrated that the functional activity of white-matter is of great significance and has given us insights into revealing the mechanisms of brain disorders.

Materials and methods

Using resting-state fMRI data, we adopted a clustering analysis to identify the white-matter functional networks and calculated functional connectivity between these networks in 16 DM1 patients and 18 healthy controls (HCs). A two-sample t

SUBMITTER: Li J 

PROVIDER: S-EPMC9377538 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature