Impact of Epstein-Barr virus co-infection on natural acquired Plasmodium vivax antibody response.

ABSTRACT:

Background

The simultaneous infection of Plasmodium falciparum and Epstein-Barr virus (EBV) could promote the development of the aggressive endemic Burkitt's Lymphoma (eBL) in children living in P. falciparum holoendemic areas. While it is well-established that eBL is not related to other human malaria parasites, the impact of EBV infection on the generation of human malaria immunity remains largely unexplored. Considering that this highly prevalent herpesvirus establishes a lifelong persistent infection on B-cells with possible influence on malaria immunity, we hypothesized that EBV co-infection could have impact on the naturally acquired antibody responses to P. vivax, the most widespread human malaria parasite.

Methodology/principal findings

The study design involved thre

SUBMITTER: Dias MHF 

PROVIDER: S-EPMC9377613 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature