Data-driven Normative Reference of Pediatric Cranial Bone Development.

ABSTRACT: Available normative references of cranial bone development and suture fusion are incomplete or based on simplified assumptions due to the lack of large datasets. We present a fully data-driven normative model that represents the age- and sex-specific variability of bone shape, thickness, and density between birth and 10 years of age at every location of the calvaria.

Methods

The model was built using a cross-sectional and multi-institutional pediatric computed tomography image dataset with 2068 subjects without cranial pathology (age 0-10 years). We combined principal component analysis and temporal regression to build a statistical model of cranial bone development at every location of the calvaria. We studied the influences of sex on cranial bone growth, and our bone density model

SUBMITTER: Liu J 

PROVIDER: S-EPMC9377678 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature