Airflow Limitation Increases Lung Cancer Risk in Smokers: The Lifelines Cohort Study.

ABSTRACT:

Background

The relationship between smoking, airflow limitation, and lung cancer occurrence is unclear. This study aims to evaluate the relationship between airflow limitation and lung cancer, and the effect modification by smoking status.

Methods

We included participants with spirometry data from Lifelines, a population-based cohort study from the Northern Netherlands. Airflow limitation was defined as FEV1/FVC ratio < 0.7. The presence of pathology-confirmed primary lung cancer during a median follow-up of 9.5 years was collected. The Cox regression model was used and hazard ratios (HR) with 95% confidence interval (95% CI) were reported. Adjusted confounders included age, sex, educational level, smoking, passive smoking, asthma status and asbestos exposure. The effect mod

SUBMITTER: Du Y 

PROVIDER: S-EPMC9377735 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature